Herbicides that inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD) can be mixed with herbicides that generate reactive oxygen species (ROS) to enhance the spectrum, level, speed, and consistency of weed control efficacy; however, mixtures of these herbicides can increase corn injury. A total of five field trials were conducted from 2021 to 2023 in Ridgetown, Ontario, to determine the sensitivity of two corn hybrids (‘DKC39-97’ and ‘B79N56PWE’) to tolpyralate plus ROS-generating herbicides (atrazine, bromoxynil, bentazon, or glufosinate) applied postemergence at the recommended rate (1×) and sequentially to represent a spray overlap (2×) in the field. Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused greater corn injury to DKC39-97 than B79N56PWE corn at 1, 2, and 4 wk after treatment (WAT). Tolpyralate plus atrazine, bromoxynil, bentazon, or glufosinate (2× rates) caused 38%, 36%, 29%, and 18% injury to DKC39-97 corn, but only 5%, 20%, 9%, and 2% injury to B79N56PWE corn, respectively at 1 WAT. Corn injury to both hybrids decreased over time with ≤2% injury at 8 WAT. Tolpyralate + atrazine, bromoxynil, or bentazon (2× rates) caused a 17%, 16%, and 13% height reduction, respectively, of DKC39-97 corn at 2 WAT; however, tolpyralate + glufosinate did not reduce DKC39-97 corn height. Tolpyralate + bromoxynil or bentazon (2× rates) caused a 12% and 10% height reduction of B79N56PWE corn, respectively, at 2 WAT; however, tolpyralate + atrazine or glufosinate did not reduce B79N56PWE corn height. Tolpyralate + atrazine or glufosinate (2× rates) caused a greater corn height reduction of DKC39-97 corn than B79N56PWE corn at 2 WAT. Grain yield was on average 2% lower from DKC39-97 than B79N56PWE corn. Tolpyralate + bromoxynil or bentazon (2× rates) caused 7% and 6% corn grain yield reduction compared to tolpyralate plus glufosinate (2× rate). Results indicate that tolpyralate + ROS-generating herbicides can cause corn injury, which is influenced by corn hybrid and ROS-generating herbicide. Corn producers need to consider the differential sensitivity of corn hybrids and ROS-generating herbicides when using an HPPD-inhibiting herbicide for weed management.

Nomenclature: Atrazine; bentazon; bromoxynil; glufosinate-ammonium; tolpyralate; kochia, Kochia scoparia L.; redroot pigweed, Amaranthus retroflexus L.; barnyardgrass, Echinochloa crus-galli (L.) P. Beauv.; horseweed, Erigeron canadensis (L.) Cronq.; common ragweed, Ambrosia artemisiifolia L.; waterhemp, Amaranthus tuberculatus var. rudis; foxtails, Setaria spp.; corn, Zea mays L.