Trifludimoxazin is a new herbicide that inhibits protoporphyrinogen oxidase (PPO) and is targeted for commercial market introduction in North America, South America, and Asia. It will be available both as a stand-alone product and in a 1:2 mixture with saflufenacil. The herbicide is intended for use in preplant burndown and preemergence applications in cereal, corn (Zea mays L.), soybean [Glycine max (L.) Merr.], and pulse crops to control a variety of annual broadleaf and grass weed species. Additionally, it is intended to be used in tree crops, oil palm (Elaeis guineensis Jacq.), and non-crop areas. In this study, we meticulously evaluated the performance and effectiveness of both the stand-alone herbicide and the innovative mixture concept in combating prevalent weeds commonly encountered in corn and soybean fields. Our findings revealed that both products exhibited exceptional efficacy, significantly reducing the presence of these troublesome weeds. Furthermore, the mixture concept not only demonstrated commendable soil mobility but also showcased impressive residual activity, positioning it as a powerful tool for sustainable weed control. These promising effects are further substantiated by our comprehensive adsorption–distribution–metabolism–extraction (ADME) studies, which provide insight into the behavior and longevity of the herbicides in the agricultural ecosystem.