This paper is the second in a series providing distributional and biological notes for 52 species and subspecies of Meloidae in the U.S.A. and Mexico in the genera Epicauta Dejean, 1834, Eupompha LeConte, 1858, Gnathium Kirby, 1818, Linsleya MacSwain, 1951, Lytta Fabricius, 1775, Meloe Linnaeus, 1758, Nemognatha Illiger, 1807, Phodaga LeConte, 1858, Pyrota Dejean, 1834, and Rhyphonemognatha LeConte, 1854. These include three new country records, 35 new state records, three new adult activity dates, six new host records, and numerous range extensions.