A new species, Santinezia noctiscansor, most similar to members of the S. festae group, is described from central Panama; this species is the only member of the genus that occurs in Central America. Our examinations of adults and nymphs collected from Coclé and Panamá Provinces revealed that males are sexually mature as penultimate nymphs. The subadult strongly resembles the adult with respect to coloration, scutal outline, armature of femora III–IV, and penis morphology, but differs in having fewer tarsomeres on each leg, a smaller body size (scutal length and width), and a much smaller tubercle on the ventral surface of coxa IV. Natural history observations are provided for specimens collected from the field site in Coclé Province.