A bryophyte inventory in the Serra do Aracá, Amazonas State, a sandstone tepui in northern Brazil (Guiana Shield), yielded 169 species in 68 genera and 29 families. Seven species are new to Brazil and 26 are new records for the north of the country. The Serra do Aracá holds 28% of the total number of bryophyte species recorded for northern Brazil. The most common families were Lejeuneaceae (31% of all species), Lepidoziaceae (14%), and Plagiochilaceae (6%) for liverworts, and Sematophyllaceae (7%), and Dicranaceae and Calymperaceae (6% each) for mosses. Together these six families accounted for half of the genera and almost 69% of the species collected. Seven distribution patterns were recognized, with species showing Tropical American distributions (49%). About 50% of the species are widespread in the country, nine being endemic to Brazil, and four restricted to the northern region. The results represent an increase in knowledge of the Brazilian bryoflora, being relevant for the conservation of bryophyte diversity in the Amazon Forest.