The macrolichens are a conspicuous component of the montane rainforest of Gran Piedra, Santiago de Cuba. This study aims at comparing the species composition, frequency and cover area of epiphytic macrolichens between the north and south slopes, as well as to determine the variation in species composition and frequency of epiphytic macrolichens in communities along and around the tree trunk. Six plots were sampled; three on the north-facing slope and three on the south slope. We found 21 species of macrolichens. Sticta beauvoisii, Hypotrachyna lineariloba and Pannaria tavaresii are new records for Cuba. Differences were observed in species composition between slopes, whereas neither the species composition nor the frequency changed significantly with cardinal orientation or vertical distribution on the trunk. Heterodermia leucomelaena and Leptogium austroamericanum were considered as indicators of the north slopes, and Cladonia ceratophylla of the south slope.