Many K–16 educators agree that active learning is a key component for student success in life sciences. At the same time, some instructors are frustrated by inconsistent student participation in these activities and may revert to traditional teaching strategies. Horse caregivers face a similar frustration when they lead a horse to water and it will not drink. However, they do not stop offering water. Instead, horse caregivers consider two possibilities: the horse is not thirsty or the water is not good. In this article, we apply horse sense to student engagement. We start by framing common challenges within two larger categories: student mindset (“Are the student's thirsty?”) and activity design (“Is the water good?”). For each challenge, we subsequently provide strategies to intentionally increase student learning while also empowering instructors to keep perspective.