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13 February 2024 A Tool to Teach Evolution of Protein Sequences and Structures: Prediction of Protein Structure by Building Homology Models
Agnieszka Szarecka, Christopher Dobson
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Abstract

Computer modeling and protein structure visualization tools are effective and engaging ways of presenting various molecular biology concepts to high school and college students. Here, we describe a series of activities and exercises that use online bioinformatics databases and programs to search for and obtain protein sequence and structure data and use it to build homology models of proteins. Exercises in homology modeling can serve the pedagogical purpose of introducing and illustrating the concept of homology within gene and protein families, which results in conservation of the 3D structures of proteins and allows us to predict structures when experimental data are not available.

Agnieszka Szarecka and Christopher Dobson "A Tool to Teach Evolution of Protein Sequences and Structures: Prediction of Protein Structure by Building Homology Models," The American Biology Teacher 86(2), 108-115, (13 February 2024). https://doi.org/10.1525/abt.2024.86.2.108
Published: 13 February 2024
JOURNAL ARTICLE
9 PAGES

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KEYWORDS
Bioinformatic databases
homology modeling
Protein structure prediction
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