We describe two new species of Manihot (Euphorbiaceae), and present an updated description of M. pusilla and a synonymization of M. stipularis to M. pusilla. Manihot bellidifolia, and M. longiracemosa found in campos rupestres and cerrado vegetations, reinforce the preference of this genus for habitats with restricted water availability. The two species described here are threatened with extinction, in the category of vulnerable. Manihot stipularis is considered a synonym of M. pusilla due to the wide morphological variation of its stipules, the principal character used to distinguish these species.