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1 September 2015 PHARMACOKINETIC PROPERTIES OF A SINGLE ADMINISTRATION OF ORAL GABAPENTIN IN THE GREAT HORNED OWL (BUBO VIRGINIANUS)
Taylor J. Yaw, Bianca A. Zaffarano, Andrew Gall, June E. Olds, Larry Wulf, Efthimia Papastavros, Johann F. Coetzee
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Abstract

Gabapentin (1-[aminomethyl] cyclohexane acetic acid) is a γ-aminobutyric acid analogue that has been shown to be efficacious for neuropathic pain control in humans. Plasma gabapentin concentrations >2 μg/ml are considered effective in treating epilepsy in humans and are suggested to provide analgesia for neuropathic pain. This study investigated the pharmacokinetics of a single oral dose of gabapentin suspension (11 mg/kg) in great horned owls (Bubo virginianus). Plasma gabapentin concentrations were determined in six healthy birds for 48 hr using high-performance liquid chromatography with mass spectrometric detection. Plasma gabapentin concentrations were estimated by noncompartmental pharmacokinetic analysis. The harmonic mean (±SD) maximum concentration (Cmax), time to maximum concentration (Tmax), and elimination half-life (tv2λZ) for gabapentin (11 mg/kg) were 6.17 ± 0.83 μg/ml, 51.43 ± 5.66 min, and 264.60 ± 69.35 min, respectively. In this study, plasma gabapentin concentrations were maintained above 2 μg/ml for 528 min (8.8 hr), suggesting that gabapentin administered orally every 8 hr may be appropriate in great horned owls.

Copyright 2015 by American Association of Zoo Veterinarians
Taylor J. Yaw, Bianca A. Zaffarano, Andrew Gall, June E. Olds, Larry Wulf, Efthimia Papastavros, and Johann F. Coetzee "PHARMACOKINETIC PROPERTIES OF A SINGLE ADMINISTRATION OF ORAL GABAPENTIN IN THE GREAT HORNED OWL (BUBO VIRGINIANUS)," Journal of Zoo and Wildlife Medicine 46(3), 547-552, (1 September 2015). https://doi.org/10.1638/2015-0018.1
Received: 29 January 2015; Published: 1 September 2015
KEYWORDS
analgesia
Bubo virginianus
gabapentin
Great Horned Owls
neuropathic pain
pharmacokinetics
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