An epizootic of canine distemper (CD) virus infection is described among raccoons and gray foxes in urban Sarasota County, Florida. The epizootic persisted for 2 years with a total of 114 raccoons and 8 gray foxes being handled by Sarasota County Animal Control. Virus was isolated from clinically ill raccoons on two separate occasions, 7 months apart. CD antibodies were detected in 54.5% of a sample comprising both clinically ill and apparently normal raccoons. The incidence of CD in dogs in the county did not increase during the 2 year period.