The most recent treatments of the family Cactaceae for Uruguay are that of Arechavaleta (1905), Osten (1941), and Herter (1953–55). While the globular members of the family (Parodia [including Notocactus], Frailea, and Gymnocalycium) are relatively well known through numerous later individual publications, the epiphytic species of Lepismium and Rhipsalis are comparatively poorly-known. Based on herbarium material and recent collections, we present data on the geographical distribution and taxonomy for two species of Lepismium and two species of Rhipsalis. Lepismium cruciforme and Rhipsalis floccosa are new records for the flora of Uruguay. The occurrence of Epiphyllum phyllanthus in Uruguay could not be confirmed.