A bryophyte inventory was conducted at Bixby State Park and Preserve in Iowa's Paleozoic Plateau from 2011 to 2016. 779 specimens were collected representing 105 species of bryophytes, including 93 moss species and 12 liverworts. No hornworts were found. Dicranum schreberiana (Hedwig) Hilferty ex H. A. Crum & L. E. Anderson is reported new to Iowa. 68 bryophyte species were collected from algific talus slopes near cold air vents, including 16 mosses and 1 liverwort that are uncommon elsewhere at Bixby. 39 bryophyte species were collected from the small prairie remnant in the park, of which 10 are rare in other habitats at Bixby. 23 bryophyte species were collected from the white pine (Pinus strobus L.) stand, including 2 mosses and one liverwort that were not collected elsewhere in the park. Bryophytes occurring in special habitats at Bixby are not restricted to these habitats elsewhere in Iowa and North America.