A new species of sisorid catfish in the genus Exostoma is described from the upper Irrawaddy River drainage in northern Myanmar. The new species can be distinguished from congeners by the condition of the posterior extremity of the adipose-fin base, the degree of tuberculation in the preorbital area, as well as morphometric data for the nasal barbel length, snout length, interorbital distance, adipose fin-base length, body depth at anus, caudal-peduncle length, and caudal-peduncle depth. The taxonomic status of congeners in the Irrawaddy River drainage is also discussed, and E. chaudhurii is revalidated as a distinct species.