Invasive species such as the cane toad (Rhinella marina) can be detrimental to the ecosystems they invade, and can cause a decline of native species diversity. Introduced in Puerto Rico since the 1920's, the cane toad can be found across the whole island. We present the first known record of a predation attempt of Grant's blindsnake (Typhlops granti) by a cane toad in Cabo Rojo, Puerto Rico. Grant's blindsnake is endemic to Puerto Rico and is considered endangered. Observations such as this one help to better understand the effects of the cane toad on Puerto Rico's trophic chain.