Various preemergence (PRE), PRE followed by postemergence (POST), and POST weed control options for conventional soybean were evaluated. More than 90% control of selected weed species were observed for most treatments. However, weed interference in plots treated with S-metolachlor metribuzin or S-metolachlor metribuzin cloransulam-methyl resulted in reduced soybean yield.