Grant, C. A. 2014. Use of NBPT and ammonium thiosulphate as urease inhibitors with varying surface placement of urea and urea ammonium nitrate in production of hard red spring wheat under reduced tillage management. Can. J. Plant Sci. 94: 329-335. Field studies were conducted at two locations over 3 yr to evaluate the effect of surface placement of urea ammonium nitrate (UAN) and urea fertilizers, with and without the urease inhibitor N-(n-butyl) thiophosphoric triamide (NBPT) on straw and grain yield of hard red spring wheat (Triticum aestivum L.) grown under reduced tillage management. Ammonium thiosulphate (ATS) was also evaluated as a urease inhibitor with UAN. Surface sprayed applications of UAN were frequently less effective than dribble-banded UAN applications or broadcast or dribble-banded urea in increasing grain or straw yield of hard red spring wheat. Use of NBPT with the sprayed UAN increased its effectiveness, so that grain and straw yields were similar to those with urea or with surface dribble-banded UAN. Addition of NBPT to broadcast or banded urea did not increase straw or grain yield under the conditions of this study. While there was some indication that use of ATS with UAN may have had a limited effect on fertilizer efficiency, it did not increase final grain yield as compared with dribble-banded or spray UAN applied alone or with NBPT. If surface nitrogen (N) applications are used in reduced tillage systems, spray applications of UAN should be avoided in favour of dribble-band applications, or the use of urea. Alternately, NBPT may be effective in improving the efficacy of spray UAN.