The soybean industry in Canada is seeking opportunities to expand cultivation due to economic and environmental benefits of growing soybean. Climate projections indicate that soybean expansion into Saskatchewan would be possible with the increases in the available crop heat units under a future warmer climate; however, crop water availability could limit yields. Using a crop growth model, we simulated soybean yields within the Canadian Regional Agricultural Model regions in Saskatchewan for the near-term (2030s), mid-term (2050s), and distant future (2070s) periods under different climate scenarios. Soybean yields were simulated without water stress (potential yield), with water stress (rainfed yield), and under full and partial irrigation scenarios. Irrigation water needs were estimated under the irrigation scenarios and irrigation water availability was discussed. Our results suggest that reasonable and likely more profitable yields (∼2000–2500 kg ha⁻¹) can be achieved under rainfed conditions in the Black soil zone neighbouring Manitoba but soybean production would be less favourable in the Dark Brown soil zone and least favourable in the Brown soil zone. Northeastern regions in the Black soil zone were found to be suitable for growing soybean cultivars in the maturity group (MG) 0 in the distant future and MG 00 in the mid-term under the medium–high greenhouse gas emission scenarios. Soybean would still not be suitable in the northwestern region. Our results indicate that regions in central Saskatchewan requiring 120–170 mm of irrigation are more likely to benefit from the proposed Lake Diefenbaker Irrigation Projects in the future.