The aim of this study was to determine effects of dietary microencapsulated Enterococcus faecalis CG1.0007 probiotic and multienzyme complex (MC) in Enterotoxigenic Escherichia coli K88 (ETEC) challenged piglets. Thirty-six, 21-d-old weanling pigs were randomly allotted to four dietary treatments: a wheat–barley based negative control (NC), NC + MC, NC + probiotic, and NC + MC + probiotic. After 7-d acclimatization to treatments, pigs were weighed, blood was sampled, and then the pigs were orally challenged with an ETEC inoculum. After the challenge, blood was sampled at different time points; performance measures and fecal consistency scores were recorded; and on day 14, all pigs were killed to obtain intestinal tissue samples. During prechallenge, pigs receiving enzyme, probiotic, and a combination of both showed a significant improvement in daily gain (P = 0.03) and feed efficiency (P = 0.04) compared with control. During the postchallenge period, a greater (P = 0.05) ileal villus height was observed for diets supplemented with probiotic alone. Overall, pigs fed diets with probiotic alone also showed less incidence of diarrhea (P = 0.04) compared with control. In summary, the results indicate that dietary supplementation with microencapsulated Enterococcus faecalis CG1.0007 in weaned piglets challenged with ETEC was effective in controlling diarrhea.