This study is to evaluate the effects of mineral detoxified nano-sulfur dispersion (DSD) on growth performance, fecal score, fecal microbiota, gas emissions, blood profile, nutrient digestibility, and meat quality in finishing pigs. A total of 160 pigs with an initial body weight (BW) of 54.90 ± 5.10 kg were randomly assigned to two treatments including basal diet and basal diet with 10 ppm DSD. During the 10 wk trial, there were no differences in BW, average daily gain, average daily feed intake, and gain to feed ratio between the control and DSD groups. Also, the fecal score, fecal microbiota, gas emission were not affected by DSD diet. Dietary inclusion of DSD tended to increase water-holding capacity and decrease cooking loss and drip loss. At week 5, serum concentrations of glucose, calcium (Ca), total cholesterol, and high-density level cholesterol were increased, and triglyceride concentration was reduced in pigs fed with DSD than control diets. In summary, the inclusion of dietary DSD in the finishing pig diet has improved serum Ca, glucose concentrations, and lipid profiles as well as improves some meat quality traits.