A new species, Agave cremnophila, is described from Cerro las Flores in the state of Oaxaca, Mexico. It is a small-sized species in the group Striatae and is endemic to Oaxaca; the closest relatives, based on flower and leaf morphology, are Agave dasylirioides Jacobi & Bouché from the cliffs near Tepoztlán, Morelosl the recently described A. kavandivi A. J. García-Mendoza & C. Chávez-Rendón from Cerro Kava Ndivi in western Oaxaca, and A. stricta Salm-Dyck from southern Puebla and northern Oaxaca. The addition of Agave cremnophila brings to 10, the total number of species in the Striatae, all found in Mexico.