Eight species of Cuspidariidae belonging to the genera Myonera Dall, 1886, Octoporia Scarlato and Starobogatov, 1983, and Protocuspidaria Allen and Morgan, 1981 were obtained in samples from the continental slope (700-2000 m depth) at Campos Basin, Rio de Janeiro state (22°S), Brazil. Myonera paucistriata Dall, 1886 and Protocuspidaria verityi Allen and Morgan, 1981 are now documented from the Campos Basin. Though previously reported for Brazil, the known range of Octoporia octaporosa (Allen and Morgan, 1981) is enlarged southward. Myonera limatula (Dall, 1881) and Protocuspidaria atlantica Allen and Morgan, 1981 are reported from the South Atlantic Ocean for the first time. Myonera kaiwa sp., nov. and Protocuspidaria jarauara sp. nov. are described herein. Myonera sp., an eighth taxon, is present as one unique specimen. The presence of micro-pits on the shell surface is reported for the first time in the Septibranchia.